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Phenotypes Associated with This Genotype
Genotype
MGI:5812676
Allelic
Composition
Ptentm1Mro/Ptentm1Mro
Sdhbtm1.1Ics/Sdhb+
Tg(KLK3-cre)D4Trp/0
Genetic
Background
involves: 129S2/SvPas * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Mro mutation (1 available); any Pten mutation (39 available)
Sdhbtm1.1Ics mutation (0 available); any Sdhb mutation (17 available)
Tg(KLK3-cre)D4Trp mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• 89% of mice show pheochromocytoma at 12.9 months of age
• tumors do not show accumulation of succinate

neoplasm
• 89% of mice show pheochromocytoma at 12.9 months of age
• tumors do not show accumulation of succinate

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
pheochromocytoma DOID:0050771 OMIM:171300
J:236514


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/10/2020
MGI 6.16
The Jackson Laboratory