mortality/aging
• mice survive to birth but succumb shortly thereafter due to breathing problems
|
respiratory system
• mice exhibit defective structural maturation of the lungs
|
• at E13.5, lungs lobes appear globular and disorganized
|
small lung
(
J:233815
)
• at E13.5, lungs are smaller than normal
|
• neonates die from apparent respiratory distress
|