Phenotypes Associated with This Genotype

Genotype
MGI:5812368

• Allelic Composition: Fendrr^tm1Vlcg/Fendrr^tm1Vlcg
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Abnormal, disorganized, globular phenotype in the lobes of E13.5 Fendrr^tm1Vlcg/Fendrr^tm1Vlcg lungs

mortality/aging

neonatal lethality, complete penetrance ( J:233815 )

• mice survive to birth but succumb shortly thereafter due to breathing problems

respiratory system

abnormal lung development ( J:233815 )

• mice exhibit defective structural maturation of the lungs

abnormal lung lobe morphology ( J:233815 )

• at E13.5, lungs lobes appear globular and disorganized

small lung ( J:233815 )

• at E13.5, lungs are smaller than normal

respiratory distress ( J:233815 )

• neonates die from apparent respiratory distress