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Phenotypes Associated with This Genotype
Genotype
MGI:5811553
Allelic
Composition
Pus1tm1.1Mdf/Pus1tm1.1Mdf
Genetic
Background
B6.129S7(C)-Pus1tm1.1Mdf
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pus1tm1.1Mdf mutation (1 available); any Pus1 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice fatigue more quickly in exercise treadmill test exhibiting a 46% decrease in run-to-fatigue time
• no difference in grip strength or rotorod speed/time as compared to controls

cellular
• mitochondria are reduced in size in skeletal muscle, but not liver
• 45% reduction in mitochondrial density
• 33% reduction in average mitochondrial size
• increase in number of very small mitochondria

growth/size/body
• females and males have a reduced body weight as compared to wild-type mice at 7 and 14 weeks of age, respectively, however, no significant difference is observed at later ages

homeostasis/metabolism
• mice fatigue more quickly in exercise treadmill test exhibiting a 46% decrease in run-to-fatigue time
• no difference in grip strength or rotorod speed/time as compared to controls

muscle
• 24% increase in mean cross-sectional myofiber area in the tibialis anterior muscle
• however, there are no changes in percentage of extracellular matrix area or centralized nuclei
• increase is only observed in myosin heavy chain IIB expressing fibers
• females exhibit decreased muscle mass and a smaller gastrocnemius to body weight ratio at 7 weeks of age, however, by 14 weeks there is no significant difference
• reduction in oxidative capacity of myofibers
• 38% decrease in high succinate dehydrogenase (SDH) activity myofibers
• 63% reduction in cytochrome c oxidase activity in red gastrocnemius muscle


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/17/2018
MGI 6.11
The Jackson Laboratory