Phenotypes Associated with This Genotype

Genotype
MGI:5810738

• Allelic Composition: Gata3^tm1Gsv/Gata3^tm1Gsv
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

abnormal pyloric sphincter morphology ( J:228275 )

• at E18.5, embryos which have been pharmacologically rescued by in utero catecholamine treatment show a pyloric sphincter constriction that is 49% wider than that in wild-type controls

• however, positioning of the epithelial pyloric border is normal at E18.5

abnormal stomach smooth muscle circular layer morphology ( J:228275 )

• at E16.5, the shape of the dorsal inner circular muscle (ICM) is altered, secondary to the loss of the outer longitudinal muscle (OLM)

abnormal stomach smooth muscle outer longitudinal layer morphology ( J:228275 )

• pharmacologically rescued embryos display a nearly complete absence of alpha-smooth muscle actin (alpha-SMA)-positive cells in the dorsal pyloric OLM fascicle by E16.5

• however, no overt pyloric abnormalities are detected at E14.5

digestive/alimentary system

abnormal pyloric sphincter morphology ( J:228275 )

• at E18.5, embryos which have been pharmacologically rescued by in utero catecholamine treatment show a pyloric sphincter constriction that is 49% wider than that in wild-type controls

• however, positioning of the epithelial pyloric border is normal at E18.5

abnormal stomach smooth muscle circular layer morphology ( J:228275 )

• at E16.5, the shape of the dorsal inner circular muscle (ICM) is altered, secondary to the loss of the outer longitudinal muscle (OLM)

abnormal stomach smooth muscle outer longitudinal layer morphology ( J:228275 )

• pharmacologically rescued embryos display a nearly complete absence of alpha-smooth muscle actin (alpha-SMA)-positive cells in the dorsal pyloric OLM fascicle by E16.5

• however, no overt pyloric abnormalities are detected at E14.5