Phenotypes Associated with This Genotype

Genotype
MGI:5810653

• Allelic Composition: L3mbtl2^tm1.2Haho/L3mbtl2^tm1.2Haho
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis ( J:227373 )

• no homozygotes are detected after birth, with lethality after E9.5 as only debris is recovered from decidua at this time

embryo

abnormal embryo development ( J:227373 )

• at E6.5, the core of the embryos consist of an abnormal, unstructured mass of irregular cells and embryos do not show a distinct ectodermal epithelial layer, proamniotic cavity, chorion, or amnion

embryonic growth retardation ( J:227373 )

• embryos show growth retardation at and after E7.5 with little growth or development at E8.5

abnormal embryonic epiblast morphology ( J:227373 )

• inner cell mass fails to form a normal primitive ectoderm

growth/size/body

embryonic growth retardation ( J:227373 )

• embryos show growth retardation at and after E7.5 with little growth or development at E8.5