Phenotypes Associated with This Genotype

Genotype
MGI:5810178

• Allelic Composition: Eif4ebp1^tm1Nso/Eif4ebp1^tm1Nso; Mtor^tm1.1Gcon/Mtor^tm1.1Gcon; A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:163763 )

♂ • after tamoxifen (TMX) treatment, mice exhibit significantly enhanced survival relative to Mtor^tm1.1Gcon/Mtor^tm1.1Gcon A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/0 mice

cardiovascular system

cardiovascular system phenotype ( J:163763 )

♂N • at 4 weeks after TMX treatment, mice exhibit normal echocardiographic parameters, cardiomyocyte size, and cardiac function (as assessed by the LV fractional shortening %)

cardiac interstitial fibrosis ( J:163763 )

♂ • at 4 weeks after TMX treatment, mice show significantly reduced fibrosis relative to Mtor^tm1.1Gcon/Mtor^tm1.1Gcon A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/0 mice

cellular

cardiac interstitial fibrosis ( J:163763 )

♂ • at 4 weeks after TMX treatment, mice show significantly reduced fibrosis relative to Mtor^tm1.1Gcon/Mtor^tm1.1Gcon A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/0 mice

abnormal autophagy ( J:163763 )

♂ • after TMX treatment, mice show a similar expression of autophagy genes relative to Mtor^tm1.1Gcon/Mtor^tm1.1Gcon A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/0 mice, suggesting that autophagy is not involved in the amelioration of the heart failure phenotype

decreased cardiomyocyte apoptosis ( J:163763 )

♂ • at 4 weeks after TMX treatment, mice show a significant decrease of cleaved Parp protein and TUNEL+ cells in the myocardium relative to Mtor^tm1.1Gcon/Mtor^tm1.1Gcon A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/0 mice

abnormal mitochondrial physiology ( J:163763 )

♂ • at 4 weeks after TMX treatment, mice show increased cytochrome c oxidase subunit IV (CoxIV) expression in heart lysates relative to Mtor^tm1.1Gcon/Mtor^tm1.1Gcon A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/0 mice, suggesting that mitochondrial function is improved

muscle

decreased cardiomyocyte apoptosis ( J:163763 )

♂ • at 4 weeks after TMX treatment, mice show a significant decrease of cleaved Parp protein and TUNEL+ cells in the myocardium relative to Mtor^tm1.1Gcon/Mtor^tm1.1Gcon A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/0 mice

homeostasis/metabolism

abnormal autophagy ( J:163763 )

♂ • after TMX treatment, mice show a similar expression of autophagy genes relative to Mtor^tm1.1Gcon/Mtor^tm1.1Gcon A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/0 mice, suggesting that autophagy is not involved in the amelioration of the heart failure phenotype