Phenotypes Associated with This Genotype

Genotype
MGI:5810138

• Allelic Composition: Bicd2^tm1Hgrd/Bicd2^tm1Hgrd; Emx1^tm1(cre)Krj/Emx1⁺
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Abnormally oriented axonal bundles coursing from the superficial lamina towards the capsula interna in neocortex of Bicd2^tm1Hgrd/Bicd2^tm1HgrdEmx1^tm1(cre)Krj/Emx1⁺ mice

nervous system

nervous system phenotype ( J:210236 )

N • mice survive to >8 weeks (when they are sacrificed) and do not develop hydrocephalus

abnormal neuronal migration ( J:210236 )

• immunofluorescence of neurofilament-M revealed abnormally oriented axonal bundles coursing from the superficial lamina towards the capsula interna in the neocortex

abnormal hippocampus layer morphology ( J:210236 )

• mice exhibit disrupted laminar organization in the hippocampus

abnormal stratification in cerebral cortex ( J:210236 )

• mice exhibit disrupted laminar organization in the cerebral cortex

cellular

abnormal neuronal migration ( J:210236 )

• immunofluorescence of neurofilament-M revealed abnormally oriented axonal bundles coursing from the superficial lamina towards the capsula interna in the neocortex