Phenotypes Associated with This Genotype

Genotype
MGI:5810097

• Allelic Composition: Arrdc4^{tm1(KOMP)Vlcg}/Arrdc4^{tm1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6N * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell physiology ( J:236091 )

• mutant mouse embryonic fibroblasts (MEFs) show a ~30% reduction in extracellular vesicle (EV) release relative to wild-type MEFs

• in gut explants cultures, homozygotes exhibit normal levels of DMT1 (divalent metal ion transporter) released in gut EVs but show a significantly reduced protein concentration of EVs released from gut EVs relative to wild-type controls