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Phenotypes Associated with This Genotype
Genotype
MGI:5807208
Allelic
Composition		 Pik3cdm2Btlr/Pik3cdm2Btlr
Genetic
Background		 C57BL/6J-Pik3cdm2Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3cdm2Btlr mutation (0 available); any Pik3cd mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased IgE level ( J:236693 )
• some mice show an increase in the ratio of OVA-specific IgE over the total IgE due to an increase in OVA-specific IgE
decreased IgG level ( J:236693 )
• the T-dependent antibody response to ovalbumin administered with aluminum hydroxide is diminished
decreased IgM level ( J:236693 )
• the T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll) is reduced
increased circulating interferon-alpha level ( J:236693 )
• some mice show an increase in dsDNA induced type I IFN production in macrophages
increased susceptibility to Herpesvirales infection ( J:236693 )
• some mice show an increased proliferation of mouse cytomegalovirus (MCMV) in macrophages
decreased response to antigen ( J:236693 )
• the T-dependent antibody response to ovalbumin administered with aluminum hydroxide is slightly diminished
• the T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll) is slightly reduced
increased response to antigen ( J:236693 )
• some mice show an increase in the ratio of OVA-specific IgE over the total IgE due to an increase in OVA-specific IgE

homeostasis/metabolism
increased circulating interferon-alpha level ( J:236693 )
• some mice show an increase in dsDNA induced type I IFN production in macrophages

hematopoietic system
increased IgE level ( J:236693 )
• some mice show an increase in the ratio of OVA-specific IgE over the total IgE due to an increase in OVA-specific IgE
decreased IgG level ( J:236693 )
• the T-dependent antibody response to ovalbumin administered with aluminum hydroxide is diminished
decreased IgM level ( J:236693 )
• the T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll) is reduced

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory