Phenotypes for Rac2 MGI:5807145 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Rac2^m3Btlr/Rac2^m3Btlr
Genetic Background	C57BL/6J-Rac2^m3Btlr

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Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rac2^m3Btlr mutation (0 available); any Rac2 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased neutrophil cell number ( J:236680 )

increased B-1b cell number ( J:236680 )

decreased B cell number ( J:236680 )

• B cells and IgM+ B cells

decreased B-1a cell number ( J:236680 )

decreased IgM level ( J:236680 )

• diminished T-independent IgM response to 4-hydroxy-3-nitrophenylacetyl-Ficoll

decreased response to antigen ( J:236680 )

• diminished T-independent IgM response to 4-hydroxy-3-nitrophenylacetyl-Ficoll

hematopoietic system

impaired hematopoiesis ( J:236680 )

increased neutrophil cell number ( J:236680 )

increased B-1b cell number ( J:236680 )

decreased B cell number ( J:236680 )

• B cells and IgM+ B cells

decreased B-1a cell number ( J:236680 )

decreased IgM level ( J:236680 )

• diminished T-independent IgM response to 4-hydroxy-3-nitrophenylacetyl-Ficoll

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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