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Phenotypes Associated with This Genotype
Genotype
MGI:5807108
Allelic
Composition
Ppp3cbM1Btlr/Ppp3cbM1Btlr
Genetic
Background
C57BL/6J-Ppp3cbM1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp3cbM1Btlr mutation (0 available); any Ppp3cb mutation (67 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• increased frequency of central memory CD8+ T cells
• some mice show increased expression of CD44 on CD8+ T cells and an increased frequency of NK cells in the peripheral blood
• mice show an increase in the B:T cell ratio due to a reduced frequency of T cells including CD4+ T cells and CD8+ T cells
• mice show an increase in the B:T cell ratio due to a reduced frequency of T cells including CD4+ T cells and CD8+ T cells

cellular
• increased frequency of central memory CD8+ T cells

hematopoietic system
• increased frequency of central memory CD8+ T cells
• some mice show increased expression of CD44 on CD8+ T cells and an increased frequency of NK cells in the peripheral blood
• mice show an increase in the B:T cell ratio due to a reduced frequency of T cells including CD4+ T cells and CD8+ T cells
• mice show an increase in the B:T cell ratio due to a reduced frequency of T cells including CD4+ T cells and CD8+ T cells


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory