Analysis Tools
mortality/aging
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• males and females are born in equal numbers and appear healthy with no overt discomfort but exhibit sudden death by heart block between 12 and 24 weeks of age
• both males and females die at about the same age, indicating that there is no male bias in sudden death
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cardiovascular system
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• at 12-20 weeks of age, no significant differences in left ventricular wall thickness, chamber size or function are observed in male or female mice relative to control mice
• mice show no signs of increased interstitial fibrosis at ~15 weeks of age
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• at 1 hour prior to death, mice exhibit a significantly lower heart rate than control mice
• average heart rate begins to drop at ~5 days prior to death
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• all (4 of 4) mice develop sinus bradycardia, unlike control mice which show no evidence of arrhythmias
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• at 12-20 weeks of age, mice show a significant increase in the AV Wenckebach cycle length relative to control mice
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• at 1 hour prior to death, mice show longer RR intervals than control mice
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• all mice develop sinus bradycardia and die a few days later from complete atrioventricular block, unlike control mice which show no evidence of conduction defects or arrhythmias
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• at 12-20 weeks of age, mice show a significant increase in the HV-interval relative to control mice
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• at 1 hour prior to death, mice show longer QRS intervals than control mice
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