Phenotypes Associated with This Genotype

Genotype
MGI:5806532

• Allelic Composition: Asns^{tm1a(EUCOMM)Wtsi}/Asns^{tm1a(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Asns^{tm1a(EUCOMM)Wtsi}
• Cell Lines: EPD0525_1_F01

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased brain size ( J:236441 )

• at P84, brain surface area of the left hemisphere is ~5% smaller than that in heterozygous controls

enlarged lateral ventricles ( J:236441 )

• at P0, lateral ventricle area of the right hemisphere is significantly larger than that in wild-type controls

• at P84, lateral ventricle area of the left hemisphere is ~95% larger than that in heterozygous controls

abnormal cerebral cortex morphology ( J:236441 )

• at P0, cortex surface area (right hemisphere only) is on average ~5% smaller than that in wild-type controls

• at P84, cortex surface area is ~8% smaller than that in heterozygous controls

thin cerebral cortex ( J:236441 )

• at P0, cortical thickness is on average ~14% thinner than that in wild-type controls

• at P84, cortical thickness (from the edge of the hippocampus to the outer cortex) is significantly reduced relative to that in heterozygous controls

behavior/neurological

behavior/neurological phenotype ( J:236441 )

N • adult homozygotes show no differences in spontaneous locomotor activity, rotarod performance, or anxiety-like behavior in the light-dark emergence test relative to heterozygous controls

N • adult homozygotes show no evidence of behavioral or electrographic seizures, similar to wild-type controls

impaired long-term object recognition memory ( J:236441 )

• adult homozygotes are severely impaired in long-term memory in the novel object recognition task; they continue to show no object preference and significantly lower preference scores than heterozygous or wild-type controls

• however, time spent exploring the objects or total investigative contacts with the objects are not significantly altered

impaired short-term object recognition memory ( J:236441 )

• adult homozygotes are severely impaired in short-term memory in the novel object recognition task and show significantly lower preference scores for the novel object than wild-type controls

• however, time spent exploring the objects or total investigative contacts with the objects are not significantly altered