Phenotypes Associated with This Genotype

Genotype
MGI:5806470

• Allelic Composition: Tg(Ela-KRAS*G12D)9Eps/0; Tgfbr1^tm1Bopa/Tgfbr1⁺
• Genetic Background: involves: 129S1/SvImJ * C57BL/6 * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased pancreas tumor incidence ( J:231759 )

♂ • only 40% of mice present with neoplastic or metaplastic pancreatic lesions

abnormal pancreas physiology ( J:231759 )

♂ • decrease in proliferating cell nuclear antigen (PCNA) staining throughout the entire pancreas

hematopoietic system

increased CD8-positive, alpha-beta T cell number ( J:231759 )

♂ • expansion of CD8+ population in mesenteric lymph nodes

♂ • total T-cell infiltration near pancreatic lesions is increased, with strong CD8+ infiltration but almost completely absent CD3/pSMAD2+ and CD3/FOXP3+ cell (suppressive/anergic regulatory T lymphocytes) infiltration, indicating a cytotoxic response against pancreatic lesions

immune system

increased CD8-positive, alpha-beta T cell number ( J:231759 )

♂ • expansion of CD8+ population in mesenteric lymph nodes

♂ • total T-cell infiltration near pancreatic lesions is increased, with strong CD8+ infiltration but almost completely absent CD3/pSMAD2+ and CD3/FOXP3+ cell (suppressive/anergic regulatory T lymphocytes) infiltration, indicating a cytotoxic response against pancreatic lesions

neoplasm

increased pancreas tumor incidence ( J:231759 )

♂ • only 40% of mice present with neoplastic or metaplastic pancreatic lesions