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Phenotypes Associated with This Genotype
Genotype
MGI:5806468
Allelic
Composition
Tg(Ela-KRAS*G12D)9Eps/0
Tg(Mt1-TGFBR2*)AM3Epb/0
Genetic
Background
involves: C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• expansion of the pancreatic stroma
• pancreatic lesions are accompanied with more severe fibrosis and heavy matrix deposition
• mice develop pancreatic acinar-to-ductal metaplasia
• mice show extensive intraductal papillary neoplasm development and associated parenchymal loss
• increase in proliferating cell nuclear antigen (PCNA) staining throughout the entire pancreas
• mice display marked pancreatic inflammation

hematopoietic system
• total T-cell infiltration near pancreatic lesions is increased, with increased CD3/pSMAD2+ and CD3/FOXP3+ cell (suppressive/anergic regulatory T lymphocytes) infiltration but very little CD8+ infiltration

immune system
• mice display marked pancreatic inflammation
• total T-cell infiltration near pancreatic lesions is increased, with increased CD3/pSMAD2+ and CD3/FOXP3+ cell (suppressive/anergic regulatory T lymphocytes) infiltration but very little CD8+ infiltration

neoplasm
• mice show extensive intraductal papillary neoplasm development and associated parenchymal loss

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
pancreatic carcinoma DOID:4905 OMIM:260350
J:231759


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2020
MGI 6.16
The Jackson Laboratory