Phenotypes Associated with This Genotype

Genotype
MGI:5806467

• Allelic Composition: Tg(Ela-KRAS*G12D)9Eps/0
• Genetic Background: involves: C57BL/6 * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal pancreatic acinar cell morphology ( J:231759 )

♂ • mice develop background mild acinar degeneration/pancreatitis after one year

endocrine/exocrine glands

abnormal pancreas morphology ( J:231759 )

♂ • expansion of the pancreatic stroma

abnormal pancreatic acinar cell morphology ( J:231759 )

♂ • mice develop background mild acinar degeneration/pancreatitis after one year

increased pancreas tumor incidence ( J:231759 )

♂ • mice develop multiple intraductal papillary neoplasms after one year

pancreas degeneration ( J:231759 )

♂ • mice present with mild pancreatic acinar degeneration at one year of age

pancreatic acinar-to-ductal metaplasia ( J:231759 )

♂ • mice develop pancreatic acinar-to-ductal metaplasia after one year

pancreas inflammation ( J:231759 )

♂ • mice develop background mild acinar degeneration/pancreatitis after one year

hematopoietic system

increased regulatory T cell number ( J:231759 )

♂ • total T-cell infiltration near pancreatic lesions is increased, with increased CD3/pSMAD2+ and CD3/FOXP3+ cell (suppressive/anergic regulatory T lymphocytes) infiltration but very little CD8+ infiltration

immune system

pancreas inflammation ( J:231759 )

♂ • mice develop background mild acinar degeneration/pancreatitis after one year

increased regulatory T cell number ( J:231759 )

♂ • total T-cell infiltration near pancreatic lesions is increased, with increased CD3/pSMAD2+ and CD3/FOXP3+ cell (suppressive/anergic regulatory T lymphocytes) infiltration but very little CD8+ infiltration

neoplasm

increased pancreas tumor incidence ( J:231759 )

♂ • mice develop multiple intraductal papillary neoplasms after one year