Phenotypes Associated with This Genotype

Genotype
MGI:5806466

• Allelic Composition: Tg(Mt1-TGFBR2*)AM3Epb/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal exocrine pancreas morphology ( J:76993 )

• acini are replaced by primitive ductular structures harboring transitional cells, characterized by ductal morphology but containing zymogen granules

• tubular complexes resulting from dedifferentiation of acini into ductal structures are present in severely affected pancreatic lobules with increasing age

abnormal pancreatic acinus morphology ( J:76993 )

• pancreas exhibits adipose replacement of acini in the exocrine pancreas

pancreatic acinar hyperplasia ( J:76993 )

• 21% of 14 month or older mutants exhibit eosinophilic foci of acinar cells, indicating focal hyperplasia

abnormal pancreatic duct morphology ( J:76993 )

• pancreas shows ductular transformation

abnormal pancreatic acinar cell physiology ( J:76993 )

• increase in the proportion of proliferating acinar cells in the pancreas at 6 weeks and 8 months of age

• however, aberrant ductular epithelial cells in the pancreas do not show evidence of increased proliferative activity

endocrine/exocrine glands

abnormal pancreas morphology ( J:76993 )

• pancreas is lighter in color at 5 months of age

• pancreas shows neo-angiogenesis

• expansion of the extracellular matrix in the pancreas of 8 month old mice

• however, islets of Langerhans are normal

abnormal exocrine pancreas morphology ( J:76993 )

• acini are replaced by primitive ductular structures harboring transitional cells, characterized by ductal morphology but containing zymogen granules

• tubular complexes resulting from dedifferentiation of acini into ductal structures are present in severely affected pancreatic lobules with increasing age

abnormal pancreatic acinus morphology ( J:76993 )

• pancreas exhibits adipose replacement of acini in the exocrine pancreas

pancreatic acinar hyperplasia ( J:76993 )

• 21% of 14 month or older mutants exhibit eosinophilic foci of acinar cells, indicating focal hyperplasia

abnormal pancreatic duct morphology ( J:76993 )

• pancreas shows ductular transformation

decreased pancreas weight ( J:76993 )

• relative pancreatic weight is decreased at 8 months of age

pancreas fibrosis ( J:76993 )

• inter- and intralobular fibrosis develops by 5 months of age and increases progressively

pancreatic acinar-to-ductal metaplasia ( J:76993 )

• acino-ductal metaplasia is seen in some young mice and are frequently seen in older mice, often transforming entire lobules

abnormal pancreas physiology ( J:76993 )

• large numbers of apoptotic cells are seen in the pancreas of 6 week old mice

abnormal pancreatic acinar cell physiology ( J:76993 )

• increase in the proportion of proliferating acinar cells in the pancreas at 6 weeks and 8 months of age

• however, aberrant ductular epithelial cells in the pancreas do not show evidence of increased proliferative activity

pancreas inflammation ( J:76993 )

• increase in macrophage infiltration in the pancreas

immune system

pancreas inflammation ( J:76993 )

• increase in macrophage infiltration in the pancreas