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Phenotypes Associated with This Genotype
Genotype
MGI:5806144
Allelic
Composition
Lmnatm12Lgf/Lmnatm12Lgf
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnatm12Lgf mutation (0 available); any Lmna mutation (76 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• adventitial fibrosis by 4 months of age
• by 4 months of age, mice show a near-complete loss of smooth muscle cells in the media of the ascending aorta
• mice treated with an exon 11-33 antisense oligonucleotide for 3 months beginning at 1 month of age show improved aortic pathology with less adventitial fibrosis and more smooth muscle cells

muscle
• by 4 months of age, mice show a near-complete loss of smooth muscle cells in the media of the ascending aorta
• mice treated with an exon 11-33 antisense oligonucleotide for 3 months beginning at 1 month of age show improved aortic pathology with less adventitial fibrosis and more smooth muscle cells

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
progeria DOID:3911 OMIM:176670
J:234711


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2022
MGI 6.21
The Jackson Laboratory