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Phenotypes Associated with This Genotype
Genotype
MGI:5806112
Allelic
Composition
Foxg1tm1(cre)Skm/Foxg1+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxg1tm1(cre)Skm mutation (2 available); any Foxg1 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• visually evoked potential amplitudes at low spatial frequency are strongly diminished
• however, no changes in general organization, architecture and pattern or lamination of retina are seen
• cortical visual acuity is reduced at P30

nervous system
• decrease in spine density, but not spine length, in the basal dendrites of pyramidal cells (layer 2/3) in visual cortices
• the visual cortex is thinner, with specific layer II-III and layer IV reduction
• increase in interneuron density and a reduction of parvalbumin-positive cell density in layers II-III and VI of the visual cortex

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Rett syndrome DOID:1206 OMIM:312750
OMIM:613454
J:235875


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/12/2019
MGI 6.13
The Jackson Laboratory