Phenotypes Associated with This Genotype

Genotype
MGI:5806080

• Allelic Composition: Nbeal2^gps/Nbeal2^gps
• Genetic Background: 129S1/SvImJ-Nbeal2^gps

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased neutrophil cell number ( J:236370 )

• significant neutropenia with homozygotes having only 0.27 x 10³ per ul versus 0.77 x 10³ in controls

decreased platelet alpha-granule number ( J:236370 )

• homozygotes have fewer than normal platelet alpha granules

thrombocytopenia ( J:236370 )

• although mean platelet volume is normal, platelet counts are approximately one third lower than normal

enhanced megakaryocyte emperipolesis ( J:236370 )

• increased emperipolesis of neutrophils in both the spleen and bone marrow, with approximately half of the bone marrow megakaryocytes having some degree of emperipolesis

immune system

decreased neutrophil cell number ( J:236370 )

• significant neutropenia with homozygotes having only 0.27 x 10³ per ul versus 0.77 x 10³ in controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
gray platelet syndrome		DOID:0111044	OMIM:139090	J:236370