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Phenotypes Associated with This Genotype
Genotype
MGI:5805806
Allelic
Composition		 Prkd2tm1.1Shoy/Prkd2tm1.1Shoy
Prkd3tm1.1Shoy/Prkd3tm1.1Shoy
Tg(Lck-cre)1Jtak/0
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkd2tm1.1Shoy mutation (1 available); any Prkd2 mutation (43 available)
Prkd3tm1.1Shoy mutation (0 available); any Prkd3 mutation (64 available)
Tg(Lck-cre)1Jtak mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
small thymus medulla ( J:236298 )
• small and fragmented
decreased thymocyte number ( J:236298 )
• reduced CD4+ single positive thymocytes
• reduced CD4+CD8int intermediate cells

endocrine/exocrine glands
small thymus medulla ( J:236298 )
• small and fragmented
decreased thymocyte number ( J:236298 )
• reduced CD4+ single positive thymocytes
• reduced CD4+CD8int intermediate cells

hematopoietic system
small thymus medulla ( J:236298 )
• small and fragmented
decreased thymocyte number ( J:236298 )
• reduced CD4+ single positive thymocytes
• reduced CD4+CD8int intermediate cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory