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Phenotypes Associated with This Genotype
Genotype
MGI:5804696
Allelic
Composition
Cox6a1tm1(KOMP)Wtsi/Cox6a1tm1(KOMP)Wtsi
Genetic
Background
involves: C57BL/6JJcl * C57BL/6N
Cell Lines EPD0412_2_C09
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cox6a1tm1(KOMP)Wtsi mutation (2 available); any Cox6a1 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice have difficulty walking
• 7-8 week old mice show a decreased latency to fall on the rotarod

liver/biliary system
• Cox activity and ATP contents in liver cells are decreased

muscle
• neurogenic muscular changes including small angular fiber and small group atrophy
• small group atrophy

nervous system
• thinned sciatic nerves
• mice show delayed motor nerve conduction velocity

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Charcot-Marie-Tooth disease recessive intermediate D DOID:0110203 OMIM:616039
J:230212


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory