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Phenotypes Associated with This Genotype
Genotype
MGI:5804451
Allelic
Composition
Ednrbtm1.1Nrd/Ednrbtm1.1Nrd
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrbtm1.1Nrd mutation (0 available); any Ednrb mutation (74 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

The Ednrbtm1.1Nrd/Ednrbtm1.1Nrd pups are smaller and have black spots due to a melanin pigmentation defect

mortality/aging
• mice die at around weaning age (~21 days)

growth/size/body
• mice are significantly smaller than control littermates
• mice grow progressively weaker than wild-type controls

pigmentation
• P3 pups show black spots due to a melanin pigmentation defect
• mice exhibit a white coat color with black patches as early as P3

digestive/alimentary system
• mice exhibit megacolon due to abnormal dilation of the colon

integument
• P3 pups show black spots due to a melanin pigmentation defect
• mice exhibit a white coat color with black patches as early as P3


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory