Phenotypes Associated with This Genotype

Genotype
MGI:5804187

• Allelic Composition: Gucy1b2^tm3Mom/Gucy1b2^tm3Mom; Trpc2^tm1Mom/Trpc2^tm1Mom
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal physiological response to hypoxia ( J:235858 , J:307157 )

• type B olfactory sensory neurons fail to respond to reduced oxygen although they respond normally to 8-bromo-cGMP and KCl (J:235858)

• type B olfactory sensory neurons respond to NaHS but fail to respond to reduced oxygen (J:307157)

taste/olfaction

abnormal olfactory sensory neuron physiology ( J:235858 )

behavior/neurological

abnormal sensory capabilities/reflexes/nociception ( J:235858 )

• n a conditioned place aversion test to an area of low oxygen these homozygotes fail to display a preference away from the low oxygen area consistent with the failure of type B olfactory sensory neurons to respond to low oxygen

nervous system

nervous system phenotype ( J:235858 )

N • homozygotes have a normal hyperventilation response to a 10% oxygen environment

abnormal olfactory sensory neuron physiology ( J:235858 )

respiratory system

abnormal olfactory sensory neuron physiology ( J:235858 )