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Phenotypes Associated with This Genotype
Genotype
MGI:5804180
Allelic
Composition
Nr1d2tm1Dgen/Nr1d2tm1Dgen
Genetic
Background
B6;129P2-Nr1d2tm1Dgen/H
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr1d2tm1Dgen mutation (4 available); any Nr1d2 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 2 of 8 homozygotes died spontaneously at P0, within hours after birth

cardiovascular system
• in total, 4 of 15 mutant hearts displayed atrioventricular septal defects (AVSDs) and related cardiovascular malformations
• common AV valve in spontaneously deceased P0 pups
• primum ASD in spontaneously deceased P0 pups
• both spontaneously deceased P0 pups displayed AVSDs
• a single homozygote displayed an AVSD at E16.5
• a single homozygote displayed an inlet ventricular septal defect at E17.5


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory