Phenotypes Associated with This Genotype

Genotype
MGI:5803863

• Allelic Composition: \Gpx4^tm4Marc/\Gpx4^tm4Marc
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Gpx4^tm4Marc/Gpx4^tm4Marc embryos show resorptions and severe abnormalities of embryonic and extraembryonic structures

mortality/aging

embryonic lethality between implantation and placentation, complete penetrance ( J:225651 )

• homozygous embryos die at E7.5-E8.5

• an increased number of resorptions and empty decidua, but no viable embryos, are noted at E9.5

embryo

abnormal germ layer development ( J:225651 )

• a clear distinction of the three germinal layers is not possible

failure to gastrulate ( J:225651 )

abnormal embryonic tissue morphology ( J:225651 )

• severe abnormalities in embryonic structures

abnormal extraembryonic tissue morphology ( J:225651 )

• severe abnormalities in extraembryonic structures

reproductive system

empty decidua capsularis ( J:225651 )

• empty decidua at E9.5