Phenotypes Associated with This Genotype

Genotype
MGI:5803828

• Allelic Composition: Rhbdf1^{tm1b(EUCOMM)Wtsi}/Rhbdf1^{tm1b(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6N * FVB/N
• Cell Lines: EPD0577_2_H04

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:221411 )

• despite a severe reduction of mature ADAM17 protein in different brain regions, mice are viable, healthy and phenotypically indistinguishable from wild-type controls during routine handling, and survive up to at least 6 months of age with no evidence of spontaneous pathological phenotypes or histopathological brain defects

• following stimulation with phorbol ester (PMA), circulating CD45^high leukocytes isolated from brain show normal downregulation of the substrate CD62L (L-selectin) relative to wild-type controls

• LPS-stimulated release of the ADAM17 substrate TNF from resident microglia is similar to that in wild-type controls