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Phenotypes Associated with This Genotype
Genotype
MGI:5800565
Allelic
Composition
Dnm1Ftfl/Dnm1tm1.2Frk
Genetic
Background
involves: 129 * C57BL/6J * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnm1Ftfl mutation (2 available); any Dnm1 mutation (22 available)
Dnm1tm1.2Frk mutation (0 available); any Dnm1 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• due to lethal seizures

nervous system
• lethal maximal seizures with earlier onset (6 to 7 weeks) and increased severity compared with with Dnm1Ftfl heterozygotes (11 to 12 weeks)
• reduced electroconvulsive threshold compared with Dnm1Ftfl heterozygotes
• abnormal interictal EEG patterns with episodes of epileptiform spikes

behavior/neurological
• lethal maximal seizures with earlier onset (6 to 7 weeks) and increased severity compared with with Dnm1Ftfl heterozygotes (11 to 12 weeks)
• reduced electroconvulsive threshold compared with Dnm1Ftfl heterozygotes

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
idiopathic generalized epilepsy DOID:1827 OMIM:600669
J:235711


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory