Phenotypes Associated with This Genotype

Genotype
MGI:5800324

• Allelic Composition: Jup^tm1.1Chen/Jup^tm1.1Chen
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Wrinkled, looser skin, thinning of the epidermis, and lack of milk in the stomach of Jup^tm1.1Chen/Jup^tm1.1Chen pups

mortality/aging

neonatal lethality, complete penetrance ( J:222025 )

• mice die on P1

integument

thin epidermis ( J:222025 )

loose skin ( J:222025 )

• looser epidermis

wrinkled skin ( J:222025 )

abnormal skin physiology ( J:222025 )

• skin is fragile

cardiovascular system

cardiovascular system phenotype ( J:222025 )

N • mice do not show loss of cardiomyocytes, fibrosis, thinning of the ventricles, or fatty deposits in hearts, and have normal heart weight/body weight ratio