Phenotypes Associated with This Genotype

Genotype
MGI:5797530

• Allelic Composition: Cibar1^{tm1b(KOMP)Wtsi}/Cibar1^{tm1b(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Cibar1^{tm1b(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0804_2_A04

Data Sources

IMPC Data for Cibar1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased total body fat amount ( J:211773 )

♂

IMPC - WTSI

behavior/neurological

abnormal food intake ( J:274784 )

♂ • males show some aberrations in food intake

growth/size/body

increased lean body mass ( J:211773 )

♂

IMPC - WTSI

hematopoietic system

decreased erythrocyte cell number ( J:211773 )

♂

IMPC - WTSI

decreased hematocrit ( J:211773 )

♂

IMPC - WTSI

decreased hemoglobin content ( J:211773 )

♂

IMPC - WTSI

decreased leukocyte cell number ( J:211773 , J:274784 )

IMPC - WTSI ♂ (J:211773)

MGI ♂ (J:274784)

homeostasis/metabolism

decreased circulating glycerol level ( J:211773 )

♂

IMPC - WTSI

increased circulating alkaline phosphatase level ( J:211773 )

IMPC - WTSI

increased circulating amylase level ( J:211773 )

IMPC - WTSI

improved glucose tolerance ( J:211773 )

♂

IMPC - WTSI

immune system

decreased leukocyte cell number ( J:211773 , J:274784 )

IMPC - WTSI ♂ (J:211773)

MGI ♂ (J:274784)

limbs/digits/tail

abnormal digit morphology ( J:274784 )

• 28.6% of mice exhibit digit abnormalities

polysyndactyly ( J:274784 )

• 4 of 14 mice show either polysyndactyly at the phalanges or an osteoma at one of the metatarsal digits

abnormal humerus morphology ( J:211773 , J:274784 )

IMPC - WTSI (J:211773)

MGI

• 64% of mice exhibit a uni- or bilateral extra bone growth or exostosis on the deltoid tuberosity of the humerus (J:274784)

muscle

calcified tendon ( J:274784 )

• 2 of 14 mice show abnormalities at the left stifle (quadriceps tendon) consistent with tendon calcification

• 64% of mice exhibit an extra bone growth or exostosis on the deltoid tuberosity of the humerus, consistent with m. deltoideus tendon calcification

neoplasm

increased osteoma incidence ( J:274784 )

• 4 of 14 mice show either polysyndactyly at the phalanges or an osteoma at one of the metatarsal digits

skeleton

abnormal humerus morphology ( J:211773 , J:274784 )

IMPC - WTSI (J:211773)

MGI

• 64% of mice exhibit a uni- or bilateral extra bone growth or exostosis on the deltoid tuberosity of the humerus (J:274784)

calcified tendon ( J:274784 )

• 2 of 14 mice show abnormalities at the left stifle (quadriceps tendon) consistent with tendon calcification

• 64% of mice exhibit an extra bone growth or exostosis on the deltoid tuberosity of the humerus, consistent with m. deltoideus tendon calcification

increased osteoma incidence ( J:274784 )

• 4 of 14 mice show either polysyndactyly at the phalanges or an osteoma at one of the metatarsal digits

exostosis ( J:274784 )

• 64% of mice exhibit a uni- or bilateral extra bone growth or exostosis on the deltoid tuberosity of the humerus

osteophytes ( J:274784 )

• 64% of mice exhibit a uni- or bilateral extra bone growth or exostosis on the deltoid tuberosity of the humerus indicative of a deltoid spur

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
polydactyly		DOID:1148	OMIM:174200 OMIM:174500 OMIM:174700 OMIM:603596	J:274784