Phenotypes Associated with This Genotype

Genotype
MGI:5796653

• Allelic Composition: Oxr1^{tm1a(EUCOMM)Wtsi}/Oxr1^{tm1a(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Oxr1^{tm1a(EUCOMM)Wtsi}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Oxr1^{tm1a(EUCOMM)Wtsi}/Oxr1^{tm1a(EUCOMM)Wtsi} and bella/bella mice show increased apoptosis in the granule cell layer of the cerebellum

mortality/aging

premature death ( J:230923 )

behavior/neurological

ataxia ( J:230923 )

• homozygotes display ataxia to the same extent and over an identical time course as bella homozygotes

nervous system

increased neuron apoptosis ( J:230923 )

• at P21, homozygotes show a significant increase in TUNEL-positive cells in the granule cell layer of the cerebellum with a pattern and distribution equivalent to that seen in bella homozygotes

neurodegeneration ( J:230923 )

• homozygotes display progressive cerebellar degeneration to the same extent and over an identical time course as bella homozygotes

cellular

increased neuron apoptosis ( J:230923 )

• at P21, homozygotes show a significant increase in TUNEL-positive cells in the granule cell layer of the cerebellum with a pattern and distribution equivalent to that seen in bella homozygotes