Phenotypes Associated with This Genotype

Genotype
MGI:5792850

• Allelic Composition: Tg(MtTGFA)Lmb/0
• Genetic Background: involves: CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Pancreatic fibrosis and acinar-to-ductal metaplasia in Tg(MtTGFA)Lmb/0 (MT-TGFalpha) and Smad4^tm1.1Gsu/Smad4^tm1.1Gsu Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺ Tg(MtTGFA)Lmb/0 (STP) mice

endocrine/exocrine glands

abnormal pancreas morphology ( J:229184 )

• pancreas of mice provided with zinc sulfate in water undergoes progressive transformation characterized by diffuse fibrosis and altered acinar cell structure, acinar-to-ductal metaplasia, ductal proliferation, and dilatation

abnormal pancreatic acinar cell morphology ( J:229184 )

• pancreas of mice provided with zinc sulfate in water for 8 months show altered acinar structure

abnormal pancreatic islet morphology ( J:229184 )

• disruption of islet cells due to ductal proliferation and increased fibrosis is seen in mice provided with zinc sulfate

increased pancreatic intraepithelial neoplasia incidence ( J:229184 )

• mice treated with zinc sulfate water show increased numbers of ductal structures (both metaplastic ducts and/or PanIN-1 and -2)

• however, mice treated with zinc sulfate water do no develop malignant pancreatic tumors

pancreas fibrosis ( J:229184 )

• mice provided with zinc sulfate in water for 8 months exhibit diffuse fibrosis and progressive accumulation of fibrotic stroma and fibroblasts

pancreatic acinar-to-ductal metaplasia ( J:229184 )

• mice provided with zinc sulfate in water for 8 months exhibit acinar-to-ductal metaplasia

neoplasm

increased pancreatic intraepithelial neoplasia incidence ( J:229184 )

• mice treated with zinc sulfate water show increased numbers of ductal structures (both metaplastic ducts and/or PanIN-1 and -2)

• however, mice treated with zinc sulfate water do no develop malignant pancreatic tumors

digestive/alimentary system

abnormal pancreatic acinar cell morphology ( J:229184 )

• pancreas of mice provided with zinc sulfate in water for 8 months show altered acinar structure