Phenotypes for Ptf1a Smad4 Tg(MtTGFA)Lmb MGI:5792847 MGI Mouse

abnormal pancreas morphology ( J:229184 )

• activated pancreatic fibroblasts or stellate cells (PSCs) are seen in areas surrounding the ductal lesions in mice treated with zinc sulfate

abnormal pancreatic acinar cell morphology ( J:229184 )

• mice treated with zinc sulfate water for 8 months exhibit progressive dilatation of the acinar lumen due to acinar-to-ductal metaplasia

• mice treated with zinc sulfate water for 8 months show a decrease in height of acinar cells

abnormal pancreatic duct morphology ( J:229184 )

• mice treated with zinc sulfate water for 8 months exhibit increased ductal proliferation

dilated pancreatic duct ( J:229184 )

• mice treated with zinc sulfate water for 8 months exhibit pancreatic duct dilation

abnormal pancreatic islet morphology ( J:229184 )

• disruption of islet cells due to ductal proliferation and increased fibrosis is seen in mice provided with zinc sulfate

enlarged pancreas ( J:229184 )

• mice treated with zinc sulfate water for 8 months exhibit enlarged fibrotic pancreata

pancreas cyst ( J:229184 )

• mice treated with zinc sulfate water for 8 months exhibit frequent cystic formation in the pancreas due to duct dilation

pancreas fibrosis ( J:229184 )

• mice treated with zinc sulfate water for 8 months exhibit pronounced interlobular fibrosis and progressive accumulation of fibrotic stroma and fibroblasts

pancreatic acinar-to-ductal metaplasia ( J:229184 )

• mice provided with zinc sulfate in water for 8 months to induce TGFA expression exhibit acinar-to-ductal metaplasia

• proliferation within the metaplastic ductal epithelia is increased compared to single Tg(MtTGFA)Lmb hemizygotes

increased pancreatic intraepithelial neoplasia incidence ( J:229184 )

• mice treated with zinc sulfate water show increased numbers of ductal structures (both metaplastic ducts and/or PanIN-1 and -2)

• the number of PanIN-1 and -2 lesions is higher than in single Tg(MtTGFA)Lmb hemizygotes

• however, mice treated with zinc sulfate water do no develop malignant pancreatic tumors

chronic pancreas inflammation ( J:229184 )

• marker analysis shows increased upregulation of markers associated with chronic pancreatitis and desmoplasia in mice treated with zinc sulfate