Phenotypes Associated with This Genotype

Genotype
MGI:5792710

• Allelic Composition: Snrk^tm2Rra/Snrk^tm2Rra; Tg(Myh6-cre)2182Mds/0
• Genetic Background: involves: C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:218247 )

N • mice do not exhibit neonatal lethality unlike knock-out mice

premature death ( J:218247 )

• mice die between 8 to 10 months of age

cardiovascular system

cardiovascular system phenotype ( J:218247 )

N • mice exhibit normal stroke volume, left ventricle mass and heart rate

abnormal heart left ventricle morphology ( J:218247 )

• enlarged left ventricle inner diameter in systole and diastole

• increased end diastolic and end systolic volume

decreased heart left ventricle muscle contractility ( J:218247 )

• decreased ejection fraction and fractional shortening in the left ventricle

homeostasis/metabolism

abnormal lipid level ( J:218247 )

• neonatal hearts exhibit increased staining for neutral lipids using oil red O (ORO)

muscle

decreased heart left ventricle muscle contractility ( J:218247 )

• decreased ejection fraction and fractional shortening in the left ventricle