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Phenotypes Associated with This Genotype
Genotype
MGI:5792143
Allelic
Composition
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice show impaired associative memory
• mice show impaired preference for the target quadrant in the probe test of the Morris Water Maze indicating impaired spatial memory function
• mild hyperactivity

cellular
• mice show an increase in the immunoreactivity to Tom20, a marker for mitochondrial localization, in the soma, indicating accumulation of mitochondria at the somata of nerve cells and impaired mitochondrial trafficking

homeostasis/metabolism
• amyloid beta plaque

nervous system
• amyloid beta plaque

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Alzheimer's disease DOID:10652 OMIM:604154
OMIM:608907
J:234763


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/09/2018
MGI 6.12
The Jackson Laboratory