Phenotypes for Nodal Smad2 MGI:5791937 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Nodal^tm1Rob/Nodal⁺ Smad2^tm1.1Epb/Smad2⁺
Genetic Background	involves: 129S/SvEv * 129X1/SvJ * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nodal^tm1Rob mutation (2 available); any Nodal mutation (41 available)
Smad2^tm1.1Epb mutation (1 available); any Smad2 mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

holoprosencephaly ( J:183402 )

• in 1 of 41 mice between E10.5 and E12.5

embryo

embryonic growth retardation ( J:183402 )

• 15 of 41 mice exhibit anterior truncations or a severe growth delay

growth/size/body

abnormal olfactory epithelium morphology ( J:183402 )

• single field

proboscis ( J:183402 )

• in 1 of 41 mice between E10.5 and E12.5

embryonic growth retardation ( J:183402 )

• 15 of 41 mice exhibit anterior truncations or a severe growth delay

respiratory system

abnormal olfactory epithelium morphology ( J:183402 )

• single field

taste/olfaction

abnormal olfactory epithelium morphology ( J:183402 )

• single field

vision/eye

abnormal eye development ( J:183402 )

• partial failure to separate eyes in 1 of 41 mice between E10.5 and E12.5

craniofacial

abnormal olfactory epithelium morphology ( J:183402 )

• single field

proboscis ( J:183402 )

• in 1 of 41 mice between E10.5 and E12.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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