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Phenotypes Associated with This Genotype
Genotype
MGI:5791915
Allelic
Composition		 Mir34atm1.2Arte/Mir34a+
Tg(Neurod2-Smo*A1)199Jols/0
Genetic
Background		 involves: C57BL/6 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir34atm1.2Arte mutation (0 available); any Mir34a mutation (10 available)
Tg(Neurod2-Smo*A1)199Jols mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased medulloblastoma incidence ( J:221990 )
• 75% medulloblastoma incidence
• mice show increased medulloblastoma incidence and time to tumor formation compared to single Tg(Neurod2-Smo*A1)199Jols hemizygotes

nervous system
increased medulloblastoma incidence ( J:221990 )
• 75% medulloblastoma incidence
• mice show increased medulloblastoma incidence and time to tumor formation compared to single Tg(Neurod2-Smo*A1)199Jols hemizygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory