Phenotypes Associated with This Genotype

Genotype
MGI:5790675

• Allelic Composition: Notch4^tm1Grid/Notch4^tm1Grid
• Genetic Background: involves: 129S1/Sv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal retina vasculature morphology ( J:212472 )

• P5 retinas show a 17.4% reduction in the area covered by the vascular plexus relative to wild-type retinas, indicating a delay in retinal angiogenesis

• at P5, growth of the retinal vascular plexus is delayed to a greater extent than in mice homozygous for Notch4^{tm1(KOMP)Vlcg} allele

abnormal retina blood vessel morphology ( J:212472 )

• P5 retinas show a 18.7% reduction in total vessel length relative to wild-type retinas

• however, vessel length density (ratio of total vessel length to vascular area) and fractal dimension (a measure of tortuosity) remain normal

vision/eye

abnormal retina vasculature morphology ( J:212472 )

• P5 retinas show a 17.4% reduction in the area covered by the vascular plexus relative to wild-type retinas, indicating a delay in retinal angiogenesis

• at P5, growth of the retinal vascular plexus is delayed to a greater extent than in mice homozygous for Notch4^{tm1(KOMP)Vlcg} allele

abnormal retina blood vessel morphology ( J:212472 )

• P5 retinas show a 18.7% reduction in total vessel length relative to wild-type retinas

• however, vessel length density (ratio of total vessel length to vascular area) and fractal dimension (a measure of tortuosity) remain normal