Phenotypes Associated with This Genotype

Genotype
MGI:5790350

• Allelic Composition: Del(1Aim2-Ifi205)1Stsn/+; Trex1^tm1Tld/Trex1^tm1Tld
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

heart inflammation ( J:234263 )

digestive/alimentary system

stomach inflammation ( J:234263 )

• glandular stomach inflammation

immune system

increased autoantibody level ( J:234263 )

• autoantibodies against heart tissue antigens are detected

increased inflammatory response ( J:234263 )

heart inflammation ( J:234263 )

stomach inflammation ( J:234263 )

• glandular stomach inflammation

myositis ( J:234263 )

• inflammation is observed in multiple tissues including heart, tongue, skeletal muscle, glandular stomach, and kidney

kidney inflammation ( J:234263 )

mortality/aging

premature death ( J:234263 )

• mice develop a lethal autoimmune disease; death begins at 5 weeks of age

• all mice die by 30 weeks

muscle

myositis ( J:234263 )

• inflammation is observed in multiple tissues including heart, tongue, skeletal muscle, glandular stomach, and kidney

renal/urinary system

kidney inflammation ( J:234263 )