About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5789969
Allelic
Composition		 Del(1Aim2-Ifi205)1Stsn/Del(1Aim2-Ifi205)1Stsn
Trex1tm1Tld/Trex1tm1Tld
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(1Aim2-Ifi205)1Stsn mutation (1 available); any Del(1Aim2-Ifi205)1Stsn mutation (1 available)
Trex1tm1Tld mutation (2 available); any Trex1 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
heart inflammation ( J:234263 )
• autoantibodies against heart tissue antigens are detected

digestive/alimentary system
stomach inflammation ( J:234263 )
• glandular stomach inflammation

immune system
increased autoantibody level ( J:234263 )
• autoantibodies against heart tissue antigens are detected
increased inflammatory response ( J:234263 )
• inflammation is observed in multiple tissues including heart, tongue, skeletal muscle, glandular stomach, and kidney
heart inflammation ( J:234263 )
• autoantibodies against heart tissue antigens are detected
stomach inflammation ( J:234263 )
• glandular stomach inflammation

mortality/aging
premature death ( J:234263 )
• mice develop a lethal autoimmune disease; death begins at 5 weeks of age
• all mice die by 30 weeks

muscle

renal/urinary system

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory