Phenotypes Associated with This Genotype

Genotype
MGI:5789963

• Allelic Composition: Del(1Aim2-Ifi205)1Stsn/Del(1Aim2-Ifi205)1Stsn
• Genetic Background: B6(129S4)-Del(1Aim2-Ifi205)1Stsn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased macrophage apoptosis ( J:234263 )

• bone marrow derived macrophages are protected from pyroptotic cell death in response to calf thymus DNA (CT-DNA) as compared to wild type controls

hematopoietic system

decreased macrophage apoptosis ( J:234263 )

• bone marrow derived macrophages are protected from pyroptotic cell death in response to calf thymus DNA (CT-DNA) as compared to wild type controls

immune system

decreased macrophage apoptosis ( J:234263 )

• bone marrow derived macrophages are protected from pyroptotic cell death in response to calf thymus DNA (CT-DNA) as compared to wild type controls

abnormal interferon secretion ( J:234263 )

• production of type I interferon is enhanced in macrophages following transfection with dsDNA (calf thymus DNA)

decreased interleukin-1 beta secretion ( J:234263 )

• macrophages fail to secrete IL1B in response to calf thymus DNA as compared to wild type controls