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Phenotypes Associated with This Genotype
Genotype
MGI:5789737
Allelic
Composition		 Slfn2m2Btlr/Slfn2m2Btlr
Genetic
Background		 C57BL/6J-Slfn2m2Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slfn2m2Btlr mutation (0 available); any Slfn2 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased IgG level ( J:234262 )
• mice showed diminished T-dependent antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)
impaired humoral immune response ( J:234262 )
• mice showed diminished T-dependent antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)
decreased response to antigen ( J:234262 )
• mice showed diminished T-dependent antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)

hematopoietic system
decreased IgG level ( J:234262 )
• mice showed diminished T-dependent antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory