Phenotypes Associated with This Genotype

Genotype
MGI:5789729

• Allelic Composition: Rorc^m3Btlr/Rorc^m3Btlr
• Genetic Background: C57BL/6J-Rorc^m3Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased B-2 B cell number ( J:234257 )

• reduced frequency of B2 cells in the peripheral blood

increased B-1a cell number ( J:234257 )

• increased frequency of B1a cells in the peripheral blood

increased B-1b cell number ( J:234257 )

• increased frequency of B1b cells in the peripheral blood

decreased CD8-positive, naive alpha-beta T cell number ( J:234257 )

• reduced frequency of nave CD8+ T cells in CD8+ T cells in the peripheral blood

increased CD8-positive, alpha-beta T cell number ( J:234257 )

• increased frequency of CD8+ T cells in CD3+ T cells in the peripheral blood

increased effector memory CD8-positive, alpha-beta T cell number ( J:234257 )

• increased frequency of effector memory CD8+ T cells in CD8+ T cells in the peripheral blood

abnormal CD4-positive, alpha beta T cell morphology ( J:234257 )

• increased CD44+ CD4+ mean fluorescence intensity in the peripheral

increased effector memory CD4-positive, alpha-beta T cell number ( J:234257 )

• increased frequency of effector memory CD4+ T cells in CD4+ T cells in the peripheral blood

decreased CD4-positive, alpha-beta T cell number ( J:234257 )

• reduced frequency of CD4+ T cells in the peripheral blood

decreased IgG level ( J:234257 )

• the T-dependent antibody response to ovalbumin administered with aluminum hydroxide was diminished

decreased IgM level ( J:234257 )

• the T-dependent antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal) was diminished

impaired humoral immune response ( J:234257 )

• the T-dependent antibody response to ovalbumin administered with aluminum hydroxide was diminished

• the T-dependent antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal) was diminished

decreased response to antigen ( J:234257 )

• the T-dependent antibody response to ovalbumin administered with aluminum hydroxide was diminished

• the T-dependent antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal) was diminished

hematopoietic system

decreased B-2 B cell number ( J:234257 )

• reduced frequency of B2 cells in the peripheral blood

increased B-1a cell number ( J:234257 )

• increased frequency of B1a cells in the peripheral blood

increased B-1b cell number ( J:234257 )

• increased frequency of B1b cells in the peripheral blood

decreased CD8-positive, naive alpha-beta T cell number ( J:234257 )

• reduced frequency of nave CD8+ T cells in CD8+ T cells in the peripheral blood

increased CD8-positive, alpha-beta T cell number ( J:234257 )

• increased frequency of CD8+ T cells in CD3+ T cells in the peripheral blood

increased effector memory CD8-positive, alpha-beta T cell number ( J:234257 )

• increased frequency of effector memory CD8+ T cells in CD8+ T cells in the peripheral blood

abnormal CD4-positive, alpha beta T cell morphology ( J:234257 )

• increased CD44+ CD4+ mean fluorescence intensity in the peripheral

increased effector memory CD4-positive, alpha-beta T cell number ( J:234257 )

• increased frequency of effector memory CD4+ T cells in CD4+ T cells in the peripheral blood

decreased CD4-positive, alpha-beta T cell number ( J:234257 )

• reduced frequency of CD4+ T cells in the peripheral blood

decreased IgG level ( J:234257 )

• the T-dependent antibody response to ovalbumin administered with aluminum hydroxide was diminished

decreased IgM level ( J:234257 )

• the T-dependent antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal) was diminished