Phenotypes Associated with This Genotype

Genotype
MGI:5789724

• Allelic Composition: Ptpn6^m3Btlr/Ptpn6⁺
• Genetic Background: C57BL/6J-Ptpn6^m3Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased dendritic cell number ( J:234259 )

• a slight increase in the frequency of CD11c+ dendritic cells in the peripheral blood

increased B-1 B cell number ( J:234259 )

• a slight increase in the frequency of B1 cells in the peripheral blood

increased B-1a cell number ( J:234259 )

• a slight increase in the frequency of B1a cells in the peripheral blood

decreased B cell number ( J:234259 )

• a slight decrease in the frequency of B cells in the peripheral blood

decreased immature B cell number ( J:234259 )

• a slight decrease in the frequency of IgM+ B cells in the peripheral blood

decreased mature B cell number ( J:234259 )

• a slight decrease in the percentage of IgD+ B cells in the peripheral blood

decreased B-2 B cell number ( J:234259 )

• a slight decrease in the frequency of B2 cells in the peripheral blood

increased macrophage cell number ( J:234259 )

• a slight increase in the frequency of macrophages in the peripheral blood

abnormal CD8-positive, alpha beta T cell morphology ( J:234259 )

• a slight increase in the CD44 mean fluorescence intensity on CD8+ T cells in the peripheral blood

hematopoietic system

increased dendritic cell number ( J:234259 )

• a slight increase in the frequency of CD11c+ dendritic cells in the peripheral blood

increased B-1 B cell number ( J:234259 )

• a slight increase in the frequency of B1 cells in the peripheral blood

increased B-1a cell number ( J:234259 )

• a slight increase in the frequency of B1a cells in the peripheral blood

decreased B cell number ( J:234259 )

• a slight decrease in the frequency of B cells in the peripheral blood

decreased immature B cell number ( J:234259 )

• a slight decrease in the frequency of IgM+ B cells in the peripheral blood

decreased mature B cell number ( J:234259 )

• a slight decrease in the percentage of IgD+ B cells in the peripheral blood

decreased B-2 B cell number ( J:234259 )

• a slight decrease in the frequency of B2 cells in the peripheral blood

increased macrophage cell number ( J:234259 )

• a slight increase in the frequency of macrophages in the peripheral blood

abnormal CD8-positive, alpha beta T cell morphology ( J:234259 )

• a slight increase in the CD44 mean fluorescence intensity on CD8+ T cells in the peripheral blood