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Phenotypes Associated with This Genotype
Genotype
MGI:5789723
Allelic
Composition		 Ptpn6m3Btlr/Ptpn6m3Btlr
Genetic
Background		 C57BL/6J-Ptpn6m3Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptpn6m3Btlr mutation (0 available); any Ptpn6 mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased dendritic cell number ( J:234259 )
• an increase in the frequency of CD11c+ dendritic cells in the peripheral blood
increased B-1 B cell number ( J:234259 )
• an increase in the frequency of B1 cells in the peripheral blood
increased B-1b cell number ( J:234259 )
• an increase in the frequency of B1b cells in the peripheral blood
decreased B cell number ( J:234259 )
• a decrease in the frequency of B cells in the peripheral blood
decreased immature B cell number ( J:234259 )
• a decrease in the frequency of IgM+ B cells in the peripheral blood
decreased mature B cell number ( J:234259 )
• a decrease in the percentage of IgD+ B cells in the peripheral blood
decreased B-2 B cell number ( J:234259 )
• a decrease in the frequency of B2 cells in the peripheral blood
increased macrophage cell number ( J:234259 )
• an increase in the frequency of macrophages in the peripheral blood
abnormal CD8-positive, alpha beta T cell morphology ( J:234259 )
• a increase in the CD44 mean fluorescence intensity on CD8+ T cells in the peripheral blood

immune system
increased dendritic cell number ( J:234259 )
• an increase in the frequency of CD11c+ dendritic cells in the peripheral blood
increased B-1 B cell number ( J:234259 )
• an increase in the frequency of B1 cells in the peripheral blood
increased B-1b cell number ( J:234259 )
• an increase in the frequency of B1b cells in the peripheral blood
decreased B cell number ( J:234259 )
• a decrease in the frequency of B cells in the peripheral blood
decreased immature B cell number ( J:234259 )
• a decrease in the frequency of IgM+ B cells in the peripheral blood
decreased mature B cell number ( J:234259 )
• a decrease in the percentage of IgD+ B cells in the peripheral blood
decreased B-2 B cell number ( J:234259 )
• a decrease in the frequency of B2 cells in the peripheral blood
increased macrophage cell number ( J:234259 )
• an increase in the frequency of macrophages in the peripheral blood
abnormal CD8-positive, alpha beta T cell morphology ( J:234259 )
• a increase in the CD44 mean fluorescence intensity on CD8+ T cells in the peripheral blood

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory