Phenotypes Associated with This Genotype

Genotype
MGI:5789537

• Allelic Composition: Csf1r^tm1Ers/Csf1r⁺
• Genetic Background: B6.129X1-Csf1r^tm1Ers

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal learning/memory/conditioning ( J:219294 )

• mice exhibit a lower preference for the novel (re-located) object compared with controls at 6-8 months of age, indicating impaired visuospatial memory

decreased coping response ( J:219294 )

♂ • males show increased depression-like behavior at 9-11 months of age, showing longer immobility times in the forced swim test

increased anxiety-related response ( J:219294 )

♂ • 9-11 month old males spend less time in the open arm of the elevate plus maze, indicating increased anxiety

ataxia ( J:219294 )

♀ • 2 females become ataxic at 8.5 and 11 months of age

impaired coordination ( J:219294 )

• 9-11, but not 6-8, month old mice show an increase in the number of slips on a narrow round balance beam

taste/olfaction

impaired olfaction ( J:219294 )

• 9-11 month old mice show increased latency to find buried food, indicating impaired olfaction

nervous system

increased oligodendrocyte progenitor number ( J:219294 )

• increase in PDGFRalpha+ oligodendrocyte precursors in layers II-III and V of the brain

microgliosis ( J:219294 )

• increase in microglial density throughout the brain

• gene expression analysis in adult brain suggests a proinflammatory microglia phenotype

abnormal lateral ventricle morphology ( J:219294 )

• increase in lateral ventricle volume in mice with severe sensorimotor dysfunction

enlarged lateral ventricles ( J:219294 )

• increase in left ventricle size in mice with severe sensorimotor dysfunction

abnormal brain white matter morphology ( J:219294 )

• cerebral white matter lesions in mice with severe sensorimotor dysfunction

abnormal corpus callosum morphology ( J:219294 )

• thinning of the corpus callosum in mice with severe sensorimotor dysfunction

neurodegeneration ( J:219294 )

• neuronal degeneration of white matter tracts

neuron degeneration ( J:219294 )

• a proportion of mature neurons in cortical layer V are lost between 11-weeks and 10-months of age

axonal spheroids ( J:219294 )

• presence of axonal spheroids in white matter tracts

demyelination ( J:219294 )

• increase in demyelinated axons in white matter tracts

hypermyelination ( J:219294 )

• presence of hypermyelinated axons in white matter tracts

hematopoietic system

microgliosis ( J:219294 )

• increase in microglial density throughout the brain

• gene expression analysis in adult brain suggests a proinflammatory microglia phenotype

immune system

microgliosis ( J:219294 )

• increase in microglial density throughout the brain

• gene expression analysis in adult brain suggests a proinflammatory microglia phenotype

cellular

increased oligodendrocyte progenitor number ( J:219294 )

• increase in PDGFRalpha+ oligodendrocyte precursors in layers II-III and V of the brain