Phenotypes Associated with This Genotype

Genotype
MGI:5789375

• Allelic Composition: Alk^tm1.1Ics/?; Tg(Th-MYCN)41Waw/0
• Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased neuroblastoma incidence ( J:228124 , J:261033 )

• tumors are classified as neuroblastoma, stroma-poor, poorly differentiated or differentiating (J:228124)

• tumor onset occurs later than in mice carrying the Alk^tm2.1Ics allele (J:228124)

• abdominal tumors are median, perivascular and locally invasive without evidence of macroscopic tumor spread to other organs (J:228124)

• tumors at 2 or 3 locations (abdominal/thoracic/cervical) are seen in 70% of mice (J:228124)

• mice treated with vandetanib, a kinase inhibitor, or crizotinib, show a reduction in abdominal tumor weight (J:228124)

mortality/aging

premature death ( J:261033 )

• mice begin to die around 100 days of age, with 70% survival at 200-300 days of age

nervous system

increased neuroblastoma incidence ( J:228124 , J:261033 )

• tumors are classified as neuroblastoma, stroma-poor, poorly differentiated or differentiating (J:228124)

• tumor onset occurs later than in mice carrying the Alk^tm2.1Ics allele (J:228124)

• abdominal tumors are median, perivascular and locally invasive without evidence of macroscopic tumor spread to other organs (J:228124)

• tumors at 2 or 3 locations (abdominal/thoracic/cervical) are seen in 70% of mice (J:228124)

• mice treated with vandetanib, a kinase inhibitor, or crizotinib, show a reduction in abdominal tumor weight (J:228124)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
neuroblastoma		DOID:769		J:228124 , J:261033