Phenotypes Associated with This Genotype

Genotype
MGI:5788772

• Allelic Composition: Sgta^tm1.1Drmcr/Sgta^tm1.1Drmcr
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased heart weight ( J:234007 )

digestive/alimentary system

abnormal intestine morphology ( J:234007 )

• increased intestine weight

endocrine/exocrine glands

abnormal testis development ( J:234007 )

♂ • increased testis descent (AGD)

growth/size/body

increased heart weight ( J:234007 )

decreased body size ( J:234007 )

• small body size observed in both males and females beginning at P19

• feed intake, adiposity, lean and skeletal mass, when corrected for body weight, are similar to controls

decreased body weight ( J:234007 )

decreased body length ( J:234007 )

homeostasis/metabolism

decreased circulating insulin-like growth factor I level ( J:234007 )

• decreased serum IGF-1 levels

mortality/aging

lethality, incomplete penetrance ( J:234007 )

• heterozygote x heterozygote matings produced fewer female homozygotes than expected (18.80% versus 25%)

neonatal lethality, incomplete penetrance ( J:234007 )

• high neonatal death rate (30.77%) day 2 to 21

nervous system

increased brain weight ( J:234007 )

renal/urinary system

large penis ( J:234007 )

♂ • increased penis length and weight

reproductive system

abnormal testis development ( J:234007 )

♂ • increased testis descent (AGD)

large penis ( J:234007 )

♂ • increased penis length and weight

reduced fertility ( J:234007 )

decreased litter size ( J:234007 )

• litter size trends smaller for homozygote x homozygote matings