Analysis Tools
muscle
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• ectopic development of striated muscle in the CNS can be found in paralyzed adults, more frequently in spinal cord than brain
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nervous system
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• paralyzed mice often have cytoarchitectural asymmetry with distorted dorsal and ventral horns
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behavior/neurological
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• approximately 5% are reported to develop hindlimb paralysis between 4.5 and 6.5 weeks of age
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neoplasm
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• 21% of mice exhibit melanoma metastasis to sites like the liver, lung, pancreas, epididymis, femur, lymph node, and spleen
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• 22% of mice 6 months or older develop malignant melanoma
• average age of melanoma onset is 15.6 months
• melanocytic tumors occur predominantly in the skin and subcutaneous areas with heavy population of melanocytes, including the back, neck, tails, and ears, and less frequently in prepuce and the exorbital and mammary glands
• melanocytic tumors arise preferentially in males, with 17 of 19 mice with melanomas being male
• three types of melanomas are seen: epitheloid cell type resembling pigmented melanomas, spindle cell type resembling schwannomas with the Antonini type A pattern, or mixed population with epitheloid and schwannomatous components
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digestive/alimentary system
renal/urinary system
mortality/aging
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• nearly 80% die by 6 months of age, and causes is usually sporadic intestinal obstruction or progressive renal failure
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pigmentation
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• melanocytes are inappropriately abundant in the dermis, at the dermal-epidermal junction, and in the basal layer of the epidermis
• melanocytes are most heavily concentrated in the skin of the paws, tails, ears, muzzle and penis and dorsal skin
• many melanocytes are aberrantly localized to the prepuce
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integument
