Phenotypes Associated with This Genotype

Genotype
MGI:5788434

• Allelic Composition: Tg(TNFSF11)5516Edou/0; Tnfsf11^tles/Tnfsf11^tles
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

abnormal tooth eruption ( J:233240 )

• mice show rescue of lower incisor eruption but only partial rescue of upper incisor eruption

immune system

absent lymph nodes ( J:233240 )

• mice show failure of lymph node organogenesis

growth/size/body

abnormal tooth eruption ( J:233240 )

• mice show rescue of lower incisor eruption but only partial rescue of upper incisor eruption

mortality/aging

mortality/aging ( J:233240 )

N • mice exhibit normal survival

skeleton

skeleton phenotype ( J:233240 )

N • mice exhibit rescue of the osteopetrotic phenotype seen in single Tnfsf11^tles homozygotes

abnormal tooth eruption ( J:233240 )

• mice show rescue of lower incisor eruption but only partial rescue of upper incisor eruption